ABSTRACT

I. Introduction................................................................................. 117 II. Effects of Ovariectomy and Hormone Replacement

on Measures of Cholinergic Function ....................................... 118 III. Correlations with Effects of Estrogen on Cognitive

Performance ................................................................................ 121 IV. Mechanisms by Which Estrogen Affects Basal Forebrain

Cholinergic Neurons................................................................... 124 V. Conclusions and Future Directions ........................................... 125

References ............................................................................................. 126

Recent studies show that estrogen replacement can enhance specific cognitive processes in both young and older women,

and suggest that estrogen replacement can reduce the risk of Alzheimer’s-related dementia in at least some post-menopausal women.