Development of the VEGF Trap as a Novel Antiangiogenic Treatment Currently in Clinical Trials for Cancer and Eye Diseases, and Discovery of the Next Generation of Angiogenesis Targets

Normal Development and in Disease Settings......................................................... 226

9.2 VEGF Isoforms, Family Members, and Receptors ................................................. 227

9.3 Role of VEGF in Tumor Angiogenesis Supports the Notion of Blocking

VEGF as an Antitumor Strategy ............................................................................. 228

9.4 Exploiting Regeneron’s Trap Technology Platform to Create the VEGF Trap ......228

9.5 VEGF Trap Works Impressively in Preclinical Tumor Models...............................230

9.6 VEGF Trap Enters Clinical Trials for Cancer......................................................... 232

9.7 VEGF Trap Works Impressively in Preclinical Models