chapter  6
18 Pages

Chapter Value of Invertebrate Genetics and Biology to Develop Neuroprotective and Preventive Medicine in Huntington’s Disease

During the past decade, Drosophila and Caenorhabditis elegans genetics have emerged as powerful approaches for the study of cellular responses to neurodegenerative disease proteins. Such studies have provided new strategies and rationales for the development of neuroprotective drugs, such as the pharmacological manipulation of longevity modulator networks. This chapter will describe how and why these model systems may be used as ef cient translational research tools for Huntington’s disease (HD) in the discovery and development of neuroprotective drugs.