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Chapter Huntington’s Disease: Clinical Features and Routes to Therapy

In 1872, physician George Huntington reported a familial form of chorea noted previously on Long Island by his father and grandfather, also physicians. More than a century later his comments about the disease now carrying his name, Huntington’s disease (HD), remain a clear description of its major clinical features (Huntington, 1872; reprinted in Huntington, 2003). Huntington described chorea in general as the “dancing propensities of those … affected,” in whom there “seems to exist some hidden power, something that is playing tricks, as it were, upon the

Overview ....................................................................................................................1 Clinical Features ........................................................................................................4