chapter  3
30 Pages

Chapter Protein Interactions and Target Discovery in Huntington’s Disease

Huntington’s disease (HD) is a devastating neurological disorder for which we currently have no effective treatments. Although patients are typically treated with drugs that can modify symptoms, none of these current drug regimens are thought to modify the onset, progress, or ultimate fatality of HD. A major step forward in terms of understanding the mechanism underlying HD and thus toward developing rational approaches to drug development occurred in 1993 with the cloning of the

Introduction .............................................................................................................. 55 Protein Interactions Implicate Mechanisms and Target Pathways in HD ................ 56 Technologies for Detection of Protein Interactions and Protein Complexes ........... 57 Large-Scale Interaction Networks and Next-Generation Data Mining.................... 57 Transcription Protein Interactions with Huntingtin ................................................. 58 Potential Prosurvival Protein Interactions with Normal Huntingtin ........................64