ABSTRACT
The T helper type 2 (Th2) cytokines, primarily Interleukins-4, -5, and -13, control the major components that characterize an asthmatic immune response, including IgE isotype switching, mucus production, and the recruitment and activation of eosinophils. The population of Th2 cells is expanded in the airways of asthmatic subjects, and presence of these cells correlates with bronchial hyper-reactivity and airway eosinophilia, both in man and in experimental mouse models.
