ABSTRACT
Introduction .................................................................................................................................... 125 Preparation of Solid Lipid Nanoparticles....................................................................................... 126
High Shear Homogenization and Ultrasonic Dispersion .......................................................... 126 High Pressure Homogenization ................................................................................................. 126
Hot Homogenization .............................................................................................................. 127 Cold Homogenization............................................................................................................. 127
Emulsification or Vaporization Method ..................................................................................... 127 Microemulsion ............................................................................................................................ 127
Characterization of SLN.................................................................................................................. 127 SLN Incorporation and Release of Drug........................................................................................ 128 SLN for Topical Delivery ................................................................................................................ 128 SLN as a Novel Carrier System for Sunscreens.............................................................................. 131
Occlusive Effect of SLN .............................................................................................................. 132 In Vitro Occlusion of SLN .......................................................................................................... 132 SLN In Vivo Occlusion................................................................................................................ 133
Conclusions .................................................................................................................................... 134 References....................................................................................................................................... 134
Solid lipid nanoparticles (SLN) were developed at the beginning of the 1990s and attracted increasing attention during recent years as an alternative carrier system to emulsions, liposomes, and polymeric nanoparticles for controlled drug delivery [1, 2]. Drugs are typically incorporated into biodegradable lipids, which are solid at room temperature. There are three general components in SLN:lipids (such as solid triglycerides), emulsifiers, or coemulsifiers (such as soybean lecithin, egg lecithin,
phosphatidylcholine, tyloxapol, sodium cholate, sodium glycocholate, taurocholic acid sodium salt, taurodeoxycholic acid sodium salt, butanol, butyric acid, dioctyl or sodium sulfosuccinate), and the incorporated drug(s).
