ABSTRACT
I. Introduction ................................................................................................269 II. Multiple Sclerosis-The Disease ..............................................................270 III. What Did We Learn from Early Studies of Cytokines in MS?................272 IV. Measuring Cytokines in Multiple Sclerosis ..............................................273 V. The Role of Cytokines During Initiation and
Perpetuation of the Disease .......................................................................274 VI. Cytokines and Chemokines in Immune Cell
Traffic Across the Blood-Brain Barrier.....................................................278 VII. Cytokines as Effector Mechanisms in MS ................................................281 VIII. Neuroprotective Aspects of Inflammation Mediated by Cytokines ..........283 IX. Lessons from Gene Targeting Experiments
in the Animal Model of EAE ....................................................................284 X. Polymorphic Markers in Cytokine Genes and Disease Course ................285 XI. New Developments ....................................................................................289 References..............................................................................................................290
