ABSTRACT

Acknowledgments..................................................................................................161 References..............................................................................................................161

Cyclin-dependent kinases (CDKs) are eukaryotic serine or threonine protein kinases that are closely related to the prototypical Cdc2 protein (Forsburg and Nurse, 1991) and are known to associate with cyclin-related regulatory subunits. In yeast, a single CDK (Cdc28 in the budding yeast