chapter  13
26 Pages

Poly(ADP-Ribose) Polymerase Inhibition by Genetic and Pharmacological Means

Domain..............................................................................................283 13.4.3 Transgenic Mice with PARP Gene Deletion ...................................283

13.5 Chemical Inhibition of PARP.......................................................................285 13.5.1 Monocyclic Carboxamides ...............................................................286 13.5.2 Bicyclic Lactams and Bicyclic Carboxamides.................................287 13.5.3 Tri-and Polycyclic Lactams.............................................................288 13.5.4 Other PARP Inhibitors......................................................................292

13.6 Corroborative Results from Genetic and Pharmacological Inactivation of PARP ........................................................................................................294

13.7 Conclusion ....................................................................................................295 Acknowledgment ...................................................................................................295 References..............................................................................................................296

Poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30) is an abundant nuclear protein in most of the eukaryotic tissues.