ABSTRACT
Marc.Thommen@Solvias.com Abstract A new family of chiral ligands for asymmetric homogeneous hydrogenation has been developed. The performance of mono-and bis-rhodium complexes of these chiral ferrocene tetraphosphine ligands in the hydrogenation of model substrates was surveyed in comparison to their ferrocene bis-phosphine analogs. Introduction Over the past 1-2 decades, asymmetric homogeneous hydrogenation has developed into a reliable and practical technology widely used in the pharmaceutical and chemical industries to synthesize chiral molecules.1 This is due in no small part on the availability of a wide selection of chiral ligands and efficient techniques for rapid screening of catalyst systems for specific prochiral substrates.2 Bisphosphine ligands, in particular, have shown broad applicability for enantioselective hydrogenation,3 with those constructed on a ferrocene nucleus showing particular utility.4
