chapter  2
30 Pages

Neonatal Hypoxic-Ischemic Brain Insults and Their Mechanisms

Circulatory Arrest ............................................42 2.3 Mechanisms for Deplayed Neuronal Injury ..................................................43

2.3.1 Excitotoxic Mechanism ....................................................................43 2.3.1.1 Disruption of Glutamate Synapse Function........................44 2.3.1.2 Selective Vulnerability Due to Connectivity of Neuronal

Circuits................................................................................44 2.3.2 The Neurotoxic Cascase and Delayed Energy Failure ......................44 2.3.3 The Apoptosis-Necrosis Continuum..................................................45 2.3.4 Experimental Interventions to Modify Injury ....................................47