ABSTRACT
Amyloid-deposits contain fibrils and nonfibrillar components. A glycoprotein with a pentagonal structure is a constant component of all amyloid-deposits. In lung amyloidoma we observed interesting differences between parenchyma and tumour-like tissue. The polysaccharide chains are oriented parallel to the length axis of the amyloid fibrils. The chapter examines the possible sterical orientation of the oligosaccharide-component and sialic acid in amyloid-deposits and in tissue isolated amyloid fibrils using the “anisotropic” PAS-reaction and the sialic acid specific reaction. The glycoprotein components and various glycosaminglycan components: heparan-, keratane Amyloid fibrils and linearly arranged OH-groups in amyloid chondroitin sulphate and hyaluronic acid are oriented in a highly ordered fashion. The glycoprotein and sialic acid components are differently oriented in the central and peripheral regions.
