ABSTRACT

Introduction............................................................................................................199 The Challenge........................................................................................................200 MALDI Mass Spectrometry..................................................................................201 Three-Dimensional Protein Arrays........................................................................202 Leaving the MALDI Surface Behind....................................................................205 Making the Most of Undefined Protein Content ..................................................208 Summary ................................................................................................................211 Acknowledgments..................................................................................................212 References..............................................................................................................213

The discovery of protein biomarkers enables early detection and accurate prognosis of many diseases,