Calcineurin in Cell Proliferation, Cell Adhesion, and Cell Spreading
Among more than 30 target proteins activated by CaM is calcineurin. Calcineurin is a serine/threonine phosphatase. It is also known as protein phosphatase (PP)-2B. Together with PP-1, PP-2A, and PP-2C, calcineurin forms an important group of phosphatases that play a critical role in the phosphorylation/dephosphorylation cycles associated with regulation of the activity of a variety of enzymes.