chapter  11
4 Pages

Centrins (Caltractins) and Their Biological Functions

Centrin (also known as caltractin) is an EF-hand calcium-binding protein of approximately 20 kDa molecular size. Errabolu

et al.

(1994) have cloned human centrin cDNA, which contains an ORF of 516 bp and a predicted 172 amino acid residues in the protein. Sequence analysis shows that human centrin is closely related to centrins from plants, protozoa, algae, and

Xenopus

, and to CDC31 of

Saccharomyces

.