chapter  14
12 Pages

Caspases in Apoptosis, Cell Migration, Proliferation, and Neoplasia

Calcium-mediated activation of caspases is also associated with apoptosis. The apoptotic pathway involves a cascade of proteolytic events mediated by caspases, their activators, and their repressors. Caspases are cysteine proteases of a family of interleukin-1

β

-converting enzymes (ICE). A number of proteases —

ced-3, ced-4,

and

ced-9

— have been identified in the nematode

C. elegans

. Of these,

ced-3

is a caspase. A human homologue of the

ced-4

protein, called

apaf-1

, has been described (Zou

et al.