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be seen, not all volunteers had sufficient data to make this possible and there are several missing values. Subject AUC AUC Cmax Cmax Test Ref Test Ref 1 79.34 58.16 2.827 2.589 3 85.59 69.68 4.407 2.480 5 . 121.84 . 5.319 8 377.15 208.33 11.808 9.634 10 14.23 17.22 1.121 1.855 11 750.79 1407.9 6.877 13.615 13 21.27 20.81 1.055 1.210 15 8.67 . 1.084 0.995 18 269.40 203.22 9.618 7.496 20 412.42 386.93 12.536 16.106 21 33.89 47.96 2.129 2.679 24 32.59 22.70 1.853 1.727 26 72.36 44.02 4.546 3.156 27 423.05 285.78 11.167 8.422 31 20.33 40.60 1.247 1.900 32 17.75 19.43 0.910 1.185 36 1160.53 1048.60 17.374 18.976 37 82.70 107.66 6.024 5.031 39 928.05 469.73 14.829 6.962 43 20.09 14.95 2.278 0.987 44 28.47 28.57 1.773 1.105 45 411.72 379.90 13.810 12.615 47 46.88 126.09 2.339 6.977 50 106.43 75.43 4.771 4.925 The subject-profile plots (see Chapter 2) for those subjects that had values in both periods for log(AUC) and for log(Cmax) are given in Fig-ure 7.2. It is clear that for Subject 4 in the TR sequence both log(AUC) and log(Cmax) are unusually low in the second period. These plots have been drawn using a modified version of the Splus-code given in Millard and Krause (2001), Chapter 7. The SAS code to calculate the confidence intervals for log(AUC) and
DOI link for be seen, not all volunteers had sufficient data to make this possible and there are several missing values. Subject AUC AUC Cmax Cmax Test Ref Test Ref 1 79.34 58.16 2.827 2.589 3 85.59 69.68 4.407 2.480 5 . 121.84 . 5.319 8 377.15 208.33 11.808 9.634 10 14.23 17.22 1.121 1.855 11 750.79 1407.9 6.877 13.615 13 21.27 20.81 1.055 1.210 15 8.67 . 1.084 0.995 18 269.40 203.22 9.618 7.496 20 412.42 386.93 12.536 16.106 21 33.89 47.96 2.129 2.679 24 32.59 22.70 1.853 1.727 26 72.36 44.02 4.546 3.156 27 423.05 285.78 11.167 8.422 31 20.33 40.60 1.247 1.900 32 17.75 19.43 0.910 1.185 36 1160.53 1048.60 17.374 18.976 37 82.70 107.66 6.024 5.031 39 928.05 469.73 14.829 6.962 43 20.09 14.95 2.278 0.987 44 28.47 28.57 1.773 1.105 45 411.72 379.90 13.810 12.615 47 46.88 126.09 2.339 6.977 50 106.43 75.43 4.771 4.925 The subject-profile plots (see Chapter 2) for those subjects that had values in both periods for log(AUC) and for log(Cmax) are given in Fig-ure 7.2. It is clear that for Subject 4 in the TR sequence both log(AUC) and log(Cmax) are unusually low in the second period. These plots have been drawn using a modified version of the Splus-code given in Millard and Krause (2001), Chapter 7. The SAS code to calculate the confidence intervals for log(AUC) and
be seen, not all volunteers had sufficient data to make this possible and there are several missing values. Subject AUC AUC Cmax Cmax Test Ref Test Ref 1 79.34 58.16 2.827 2.589 3 85.59 69.68 4.407 2.480 5 . 121.84 . 5.319 8 377.15 208.33 11.808 9.634 10 14.23 17.22 1.121 1.855 11 750.79 1407.9 6.877 13.615 13 21.27 20.81 1.055 1.210 15 8.67 . 1.084 0.995 18 269.40 203.22 9.618 7.496 20 412.42 386.93 12.536 16.106 21 33.89 47.96 2.129 2.679 24 32.59 22.70 1.853 1.727 26 72.36 44.02 4.546 3.156 27 423.05 285.78 11.167 8.422 31 20.33 40.60 1.247 1.900 32 17.75 19.43 0.910 1.185 36 1160.53 1048.60 17.374 18.976 37 82.70 107.66 6.024 5.031 39 928.05 469.73 14.829 6.962 43 20.09 14.95 2.278 0.987 44 28.47 28.57 1.773 1.105 45 411.72 379.90 13.810 12.615 47 46.88 126.09 2.339 6.977 50 106.43 75.43 4.771 4.925 The subject-profile plots (see Chapter 2) for those subjects that had values in both periods for log(AUC) and for log(Cmax) are given in Fig-ure 7.2. It is clear that for Subject 4 in the TR sequence both log(AUC) and log(Cmax) are unusually low in the second period. These plots have been drawn using a modified version of the Splus-code given in Millard and Krause (2001), Chapter 7. The SAS code to calculate the confidence intervals for log(AUC) and
ABSTRACT