ABSTRACT
Galectin-3, previously described as IgE-binding protein, CBP35, CBP30, Mac-2, L-29, L-31, and L-34 plays an important role in tumorigenesis and progression through regulating cell proliferation, apoptosis, cell adhesion, invasion, angiogenesis, and metastasis by binding to the carbohydrate moiety of cell surface glycoproteins or glycolipids. In this chapter, multiple biological functions of galectin-3 in relation to tumorigenesis and its progression to malignant phenotype have been discussed.
