ABSTRACT
Abstract .................................................................................................................... 61 Introduction.............................................................................................................. 62
5-HT Receptors............................................................................................ 62 G Protein-Coupled Receptor-Interacting Proteins ...................................... 62 Calmodulin................................................................................................... 64
Role of CaM in 5-HT Receptor Signaling........................................ 65 Interaction of CaM with GPCRs ....................................................... 66
5-HT Receptors and Calmodulin ............................................................................ 67 5-HT
Receptor .......................................................................................... 67 Other 5-HT
Receptors ................................................................................ 70 5-HT
Receptors .......................................................................................... 70 Other 5-HT Receptors (5-HT
, 5-HT
, 5-HT
, 5-HT
) ............................... 72 Conclusions.............................................................................................................. 74 Acknowledgments.................................................................................................... 74 References................................................................................................................ 74
This chapter explores emerging roles for calmodulin as a regulator of 5-HT receptor function and describes recent work suggesting that calmodulin may be a so-called RIP (receptor-interacting protein) that binds to and modifies the functions of G protein-coupled 5-HT receptors.
