ABSTRACT
Receptor Agonists and Wound Healing ............................158 11.3 Adenosine-Mediated Transformation of Inflammatory
Response to Regeneration Response ..........................................................158 11.4 Adenosine Receptors and Matrix Production ............................................159 11.5 Adenosine Receptors and Angiogenesis.....................................................159 11.6 Adenosine Receptors and Epithelial Regeneration ....................................160 11.7 Conclusion ..................................................................................................160 References..............................................................................................................160
Rapid and complete repair of cell and tissue injury is critical to restoration of homeostasis. The organ in which wound healing is most visible is the skin; rapid restoration of the skin’s protective function maintains the integrity of the largest barrier between external pathogens and tissues. Wound healing in the skin is characterized by three nonexclusive phases: inflammation, tissue regeneration, and tissue reorganization. Inflammatory cells eliminate debris and release the signals required to promote tissue regeneration. These events occur rapidly (days to weeks), as might be expected in a process required to maintain a barrier. Tissue reorganization (scar formation) takes place over a longer period (months to years).
