ABSTRACT
Adenosine has multiple anti-inflammatory effects on human neutrophils: inhibition of phagocytosis, generation of cytotoxic oxygen metabolites, and adhesion. Several excellent reviews have been written on the immunomodulatory effects that adenosine has on neutrophils. This chapter will provide a brief overview of these effects and will focus in a little more detail on recent developments in this field, especially aspects regarding the impact of adenosine on the profile of inflammatory mediators generated by neutrophils. Possible consequences on the inflammatory response are discussed.
