ABSTRACT
Hybridization ........................................................................149 9.9 Conclusions ..................................................................................................151 References..............................................................................................................154
In the past several years, a new technology called DNA array has attracted tremendous interest among biologists. DNA arrays, macro and micro formats, present large sets of DNA sequences immobilized onto solid substrates, glass slides, or nylon membranes. Based on hybridization methods that had been used for decades to identify and quantitate the expression of single gene (e.g., Southern and Northern blots, slot blots, library screening, etc.), and with help from high-speed robotics, DNA array technology can be applied to different tasks, including genetic mapping studies, mutational analyses, and large, genome-based scale monitoring of gene expression or identification of novel genes.
