ABSTRACT
The evolution of Southern blots into filter-based screening and, with the incorporation of high-speed robotic printing, miniaturization, and fluorescence detection technologies, into the microarrays of today has created a new era in systems biology and therapeutics. Two avenues are available for microarrays, employing either amplified cDNAs (generally 0.5 to 2 kb in length) or oligonucleotides on the array. This review focuses primarily on oligonucleotide array technologies, performance, and applications.
