ABSTRACT
This chapter focuses on linear no-threshold (LNT) as the predictive theory of choice in risk assessment as used by the environmental protection agency, US nuclear regulatory commission, and other federal standards-setting agencies. The main attraction of LNT theory is that only a single parameter is needed to construct a dose-response curve and predict risk. LNT theory predicts that the risk per unit dose is the same at any dose. Thus, net damage resulting from a dose administered over a period of time would be predicted to be the same as the net damage resulting from the same dose delivered instantaneously. LNT proponents argue that base lesions and single-stranded DNA lesions occur frequently, and are readily repaired by the cell. LNT and collective dose have utility in several areas of risk assessment and risk management. Use of LNT has had serious consequences with regard to public perception of small risks and economic and social costs of managing very small risks.
