ABSTRACT
Introduction..............................................................................................................86 The Vanilloid Receptor TRPV1 and Its Endogenous Ligands, the “Endovanilloids”................................................................................................87 TRPV1 in the Resting State ....................................................................................89 Molecular Activators of TRPV1..............................................................................89 Regulation by NGF of TRPV1 May Play a Central Role in Inflammatory Hyperalgesia .................................................................................90 Modulation of TRPV1 by Protein Kinases.............................................................90 Shuffling of TRPV1 among Various Subcellular Compartments ...........................91 Regulation of TRPV1 by Mast Cells ......................................................................91 How Can a Single Receptor Mediate Responses with Dissimilar Structure-Activity Relations? ........................................................91 Diversity of Behavior of Exogenous Ligands.........................................................92 Tissue and Cellular Expression of VR1 and Its Splice Variants ............................94 Possible Regulation of TRPV1 by Splice Variants.................................................95 Regulation of TRPV1 by Serum Steroids...............................................................95 Regulation of TRPV1 by (Neuro)endocrine Factors ..............................................95 TRPV1 May Subserve Opposing Actions at the Whole Animal Level .................96 TRPV1 Is Coexpressed with Its Relatives on Sensory Neurons with Overlapping Activity .......................................................................................96 Pharmacological Overlap between TRPV1 and Its Relatives ................................96 TRPV1 Expression May Change under Pathological Conditions..........................97 Concluding Remarks ...............................................................................................98 Acknowledgments....................................................................................................98 References................................................................................................................98
