ABSTRACT

Requirement of Calcium Entry for Cell-Cycle Progression.................................105 Property of the IGF-Regulated Channel ...............................................................106 Molecular Identification of the IGF-Regulated Channel ......................................107 Regulation of TRPV2 by IGF-I ............................................................................107 Regulation of Translocation of TRPV2 ................................................................109 References..............................................................................................................112

Actions of growth factors are essential for mammalian cells to proliferate. For example, fibroblasts continue to grow in the presence of growth factors in serum, and the removal of serum attenuates proliferation. Serum-deprived cells eventually leave the cell cycle, fall into the G