ABSTRACT
Abstract ..................................................................................................................189 Introducing the TRPP Protein Subfamily .............................................................190 Mutations in TRPP2 and Polycystin-1 Cause ADPKD........................................191 Localization and Trafficking of TRPP2 ................................................................193 TRPP2: A Ca
-Regulated Cation Channel Located in the Endoplasmic Reticulum ..............................................................................194 Coassembly of PKD1 and TRPP2 Reconstitutes a Cell Surface Ca
-Permeable Cation Channel with Multiple Functions ...................................194 Activation of the PKD1-TRPP2 Complex ...........................................................195 TRPP2: A Bona Fide Mechanosensitive Channel?...............................................196 Concluding Remarks .............................................................................................199 Acknowledgments..................................................................................................199 References..............................................................................................................199
