ABSTRACT
Introduction............................................................................................................389 Expression of TRPV2 in Circulatory Organs ...........................................391 Mechanosensation of TRPV2 in Circulatory Organs ...............................391 Potential Activation Mechanisms of TRPV2 by Mechanical Stimuli...............................................................................394
Conclusions............................................................................................................394 References..............................................................................................................395
The TRPV subfamily has had increasing attention since some channels in this group have been shown to be sensitive to a broad range of environmental stimuli, including heat, osmosensitivity, and mechanical stress. In addition, TRPV proteins are widely expressed in a range of cell types in lower and higher organisms. Although some TRPVs were originally found in the sensory system, ubiquitous expression in the whole body suggests that they play important roles in both sensory and nonsensory transduction functions. All mammalian homologues of TRPVs are calciumpermeable channels, with TRPV1-4 characterized as moderately calcium-selective cationic channels (Nilius, Voets et al. 2005; O'Neil and Brown 2003; Benham, Davis et al. 2002). This calcium permeability is physiologically important because Ca
