ABSTRACT

TRP Channels: Diversity of Form and Function ......................................................2 TRP Superfamily Genes and Their Gene Products ..................................................4

TRP Subfamilies............................................................................................4 Genomic Structures .....................................................................................11 Direct Chromosomal Repeats......................................................................12

Mechanism(s) of TRPC Activation .........................................................................14 Receptor-Mediated Activation of TRPCs Requires Phospholipase C Activation: A Role for PDZ Scaffolds? ..........................14 Activation by Conformational Coupling: The Role for IP