ABSTRACT
Pulmonary fi brosis is characterized by alveolar infl ammation, mesenchymal cell proliferation, and increased production of collagen resulting in fi brous deposits, impairing the gas-exchange function of the lung. In numerous cases no causative agent or associated condition can be found and these are referred to as cryptogenic fi brosing alveolitis or idiopathic pulmonary fi brosis. In certain instances, lung fi brotic diseases may result from the pulmonary response to inhaled environmental agents, mineral or organic in nature. Interstitial pulmonary fi brosis resulting from workplace exposure to inorganic dusts (pneumoconiosis) persists throughout the world despite identifi cation of the causes and preventive measures. Pneumoconioses are presently incurable and may be progressive even after dust exposure has ceased; therefore, early recognition and preventive intervention are important.
