ABSTRACT
The basic premise underlying this chapter is that the systemic toxic manifestations of a substance can often be correlated with the plasma concentration, organ concentration, or total body burden of that substance. It follows from this premise that valuable information can be gained by considering the factors that infl uence the concentration of an agent in body fl uids and tissues following transient or chronic exposure. In this context, these factors include the deposition, absorption, distribution, and elimination of the agent after or during inhalation exposure.
