ABSTRACT
Thrombosis and embolism are responsible for approximately 80% of human strokes. Data inconsistency is the major problem in all embolic stroke models. Models of focal cerebral ischemia induced by intraarterial autologous or heterologous blood clots provided great information on the safety and efficacy of antithrombotic therapies. The infarct involved the posterior, middle, and anterior cerebral artery territories, similar to the suture ischemia model. The polyethylene microsphere-induced cerebral embolism model in rats induces widespread and irreversible formation of small emboli and multiple infarct areas in the brain. In the filament model, a monofilament is advanced into the internal carotid artery (ICA) until its tip is lodged in the anterior cerebral artery, where it blocks blood flow to the middle cerebral artery as well as to the whole ICA arterial tree, including the hypothalamic artery as it originates from the distal ICA.
