ABSTRACT
Parenteral routes of administration include injections into various compartments of the body. Sites used for collection of blood from veins may also be used for intravenous administration. Compounds to be administered to rats can be given through the gastrointestinal tract or parenteral injection. Prolonged intravenous administration/sampling may be accomplished by jugular vein or tail vein catheterization. Substances may be admitted orally by addition to the food or drinking water, by use of a capsule or pill, or by instillation into the mouth using a mechanical device, such as a syringe. Because of the expected clinical application of the compound or because of limiting factors such as solubility or irritancy, it may be necessary to consider administering substances by slow intravenous injection. The concept of microperfusion in the brain is to deliver substances through the external carotid artery to the internal carotid artery directly to the infarct areas in the brain.
