ABSTRACT
A variety of animals have been used for stroke models, including large animals and small animal species. The effect of sex on stroke was also found in human beings. N. Kagansky et al reviewed the effects of hyperglycemia on stroke in human and animal studies. Almost all in vivo experimental studies, including the evaluation of neuroprotective drugs, have been performed on young adult animals. Insulin treatment of hyperglycemic animals was found to have a beneficial effect in focal and global brain ischemia, which may be mediated by glucose reduction or by direct neuroprotection. Sometimes the animal-producing companies improve their standards for the care of animals without telling their customers; for example, they add vitamin E to the animal food, or they add more soybeans to the food, which contain more natural estrogen. The improvement of food can reduce the infarct volume due to its neuroprotective function.
