ABSTRACT
The choice of an animal model is very important to everyone who works in stroke research. Stroke models include ischemia and hemorrhage. Ischemic stroke is responsible for 85% of clinical cases; ischemic stroke models are very well studied. The most popular models of global cerebral ischemia are four-vessel occlusion and two-vessel occlusion. Focal stroke models include those for multifocal cerebral ischemia and focal hemisphere cerebral ischemia. The suture model and embolic clot model involve cervical vessel surgery without craniectomy, but the techniques are more difficult than those used in photochemical occlusion. Each drug needs to use its own model. In 2004, S. J. Murphy et al and S. M. Graham et al provided a detailed description of classifications of ischemic stroke and species used in different models. Some limitations of stroke models include variations in the size and distribution of infarction from interanimal variations in collateral flow and substantial mortality in acute and chronic survival studies.
