chapter  5
16 Pages

Physical Mechanism and Applications of CEST Contrast Agents

QUESP Experiments ..............................................................................................................89 5.4 pH Dependence of the Exchange Rate for Two Example CEST Agents, PLL and

SPD-5......................................................................................................................................93 5.5 Changes in Endogenous Protein Content Can Be Used To Detect Rat Brain Tumors

In Vivo

via CEST Imaging .....................................................................................................94 5.6 Conclusion ..............................................................................................................................96 References ........................................................................................................................................97

The imaging of cells with magnetic resonance imaging (MRI) requires some magnetic labeling strategy that allows the discrimination between labeled cells and their surroundings. To date, there are two major classes of MR contrast agents, paramagnetic agents, producing large positive signal enhancement from decreasing T