ABSTRACT

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to produce phosphatidic acid (PtdOH). DAG serves not only as a major intermediate product in the synthesis of several kinds of lipids but also as a bioactive molecule [1,2]. Therefore, DGK is thought to participate in signal transduction by modulating the levels of DAG in a variety of cellular responses to extracellular stimuli.