chapter  8
34 Pages

Genotoxicity of Explosives

Samples .............................................................................. 189 8.3 In Vivo Methodologies ................................................................................. 189

8.3.1 Mammalian In Vivo Genotoxicity Investigations ............................ 190 8.3.1.1 TNT and Its Products ......................................................... 190 8.3.1.2 Dinitrotoluenes and Their Products ................................... 191 8.3.1.3 Cyclic Nitramines and Their Products .............................. 192 8.3.1.4 Other Compounds .............................................................. 193

8.3.2 Other In Vivo Genotoxicity Investigations ....................................... 193 8.4 Structure-Activity Relationships (SARS) .................................................... 194 8.5 Application to Ecotoxicology ....................................................................... 195 8.6 New Approaches for Assessing Genotoxicity of Explosives ........................ 198 8.7 Summary ...................................................................................................... 199 8.8 Data Gaps and Future Directions ................................................................. 201 References ..............................................................................................................202