chapter  16
12 Pages

Nanotechnology.in.Drug.Delivery.for.Malaria.and.Tuberculosis.Treatment

Nanotechnology.has.gained.ground.in.the.twenty-first.century.and.is.rapidly.growing.due.to.the. ability.to.manipulate.and.harness.properties.of.assemblies.that.are.at.the.nanosize.scale.of.various. biomolecules.. In. addition,. nanotechnology. allows. scientists. to. alter. the. chemical,. physical,. and. biological.properties.of.these.assemblies,.allowing.for.their.synthesis.at.a.controlled.size.range.of. 1.to.500.nm..When.combined.with.other.biotechnology.tools.such.as.bioinformatics,.imaging,.and. systems.biology,.nanotechnology.holds.great.promises.to.address.challenges.faced.in.the.field.of. drug.development.and.delivery..Nanotechnology.may.be.used.to.modify.other.factors.such.as.localized.drug.delivery,.site-specific.activity,.periods.of.maintenance.within.the.body,.patient.compliance,.as.well.as.adverse.drug.effects..If.these.factors.are.not.controlled,.they.may.eventually.lead. to.lowered.drug.efficacy..The.challenges.for.site-specific.delivery.are.the.cellular.barriers,.which. prevent.the.drug.from.reaching.the.desired.target.[1],.thus.presenting.a.need.for.a.carrier.system.that. will.overcome.this.effect.