chapter  26
10 Pages

Physiogenomics:.Integrating.Systems.Engineering.and.Nanotechnology.for. Personalized.Medicine

A.revolution.in.our.understanding.of.human.health.and.disease.has.been.launched.by.the.sequencing.of.a.prototypical.human.genome..To.a.large.degree,.this.achievement.represents.the.pinnacle. of.reductionist.scientific.thought,.as.having.all.genes.dissected,.one.could.in.principle.allow.reconstitution.of.the.organism..In.contrast,.the.classical.discipline.of.physiology.has.been.dealing.with.

26.1. Physiogenomics.and.Nanotechnology.................................................................................299 26.1.1. Introduction............................................................................................................299 26.1.2. Fundamentals.of.Physiogenomics..........................................................................300 26.1.3. Physiotype.Models.................................................................................................. 301

26.2. Physiogenomic.Marker.Discovery.......................................................................................302 26.2.1. Association.Screening............................................................................................302 26.2.2. Physiogenomic.Control.and.Negative.Results........................................................302

26.3. Physiogenomic.Modeling....................................................................................................302 26.3.1. Model.Building.......................................................................................................302 26.3.2. Overall.Rationale....................................................................................................303 26.3.3. Model.Parameterization.........................................................................................303 26.3.4. Model.Validation....................................................................................................304 26.3.5. Multiple.Comparison.Corrections..........................................................................304 26.3.6. Summary.of.Association.Results...........................................................................305

26.4. Future.Research.and.Prospects............................................................................................306 26.4.1. Future.Research......................................................................................................306 26.4.2. Prospects.and.Conclusions.....................................................................................306

References.......................................................................................................................................307

systems.from.its.very.outset..Although.clinically.extraordinarily.relevant,.physiology.remained.an. engineering.embodiment.of.scientific.thought.distant.from.the.molecular.basis.of.function..Physiogenomics.bridges.the.gap.between.the.systems.approach.and.the.reductionist.approach.by.using. human.variability.in.physiological.process,.either.in.health.or.disease,.to.drive.their.understanding. at.the.genome.level..Physiogenomics.is.particularly.relevant.to.the.phenotypes.of.complex.diseases. and.the.clustering.of.phenotypes.into.domains.according.to.measurement.technique,.ranging.from. functional.imaging.and.clinical.scales.to.protein.serology.and.gene.expression.