ABSTRACT
Development and maturation/plasticity of adipose tissue vascularity is critical for the function of this metabolic and the endocrine organ. The proangiogenic factors, as well as the endogenous inhibitors of angiogenesis, are synthesized locally in adipose tissue. It has been proved recently that treatment of animals with antiangiogenic factors (such as anti-VEGF or its receptor antibody) dose dependently, in a reversible manner, decreases adipose tissue depot and body weight. The involvement of basal nutrient (such as fatty acids, amino acids, carbohydrates, and polyphenols) availability and energy supply signals (i.e., caloric restriction) on the “nutrient sensors” such as the mammalian target of rapamycin (mTOR) or CHOP-10/gadd 153 and the other pathways regulating adipose tissue morphogenesis are reviewed on the basis of recent knowledge. Because transcriptomics applied to obesity, as well as caloric restriction studies in humans, point to the important changes in “proand anti-inflammatory” status, the essential role of personalized nutrition in regulation of the angiogenesis-driven remodeling of the stromal vascular fraction of adipose tissue is discussed.
