ABSTRACT
This chapter discusses a novel strategy for the efficient syntheses of natural products. It provides the synthesis of a variety of their analogs utilizing combinatorial chemistry methods. The chapter describes the studies of solid-phase combinatorial synthesis for a variety of naturally occurring skeletons. The sulfonate traceless linker was also used in the combinatorial synthesis of trisaccharides. The linker is stable under acidic glycosylation conditions and is effective for the introduction of functionality at the 6-position of a glycopyranose. A combinatorial synthesis of macrosphelide analogs was carried out using a split-and-mix method using radio-frequency tags. Aurilide is a 26-membered cyclic depsipeptide that includes N-methyl amino acids, isoleucic acid, and an aliphatic acid. The synthetic strategy was highly dependent on the structure of the targeted natural product. Combinatorial short syntheses using solid phase were achieved using efficient coupling reactions of various building blocks.
