ABSTRACT

The clinical and commercial need for effective preservation and long-term storage technologies has been the impetus for recent advances in the preservation sciences. As our understanding of hypothermic storage,

in vitro

culture, cryopreservation, and dry storage continues to improve,

so

does our ability to preserve the functional viability of cells, tissues, and organs and extend the

ex

vivo

storage of these biological systems. The rapid development and adoption of cell-based therapeutics and biotechnologies is challenging current dogma and promoting the development of innovative means to protect and preserve biologics.