ABSTRACT

CONTENTS 23.1 Introduction ......................................................................................................................445

23.1.1 The New Horizons ............................................................................................445 23.1.2 The New Challenges (and Opportunities) for the Drug Developer ..........446

23.2 Agents Recently Approved, Their Mechanism of Action, and Their Trial Design for Approval ......................................................................................................446 23.2.1 Conventional Cytotoxic Agents ......................................................................446 23.2.2 New Agents with More Unique Cytostatic Mechanisms of Action