ABSTRACT
The most common clinical presentation of Primary testicular lymphoma (PTL) is a unilateral painless scrotal swelling, rarely with sharp scrotal pain. On physical examination, there is usually a unilateral non-tender firm mass. Staging procedures in PTL are similar to those applied in nodal lymphomas, with some specific requirements. Aggressive histological subtypes such as lymphoblastic lymphoma and Burkitt's lymphoma have the highest incidence of secondary testicular involvement, but secondary testicular involvement has been reported with all histological subtypes of lymphoma. Testicular lymphoma may involve testicle only, but also structures within the scrotum and regional retroperitoneal lymph nodes. Staging procedures in PTL are similar to those applied in nodal lymphomas, with some specific requirements. Testicular lymphoma is a unique extranodal presentation of Diffuse large B-cell lymphoma. Unlike some other primary extranodal lymphomas, patients with testicular lymphoma appear to have a poor prognosis and they are similar to patients who have primary central nervous system lymphoma.
