ABSTRACT
KEY TERMS: Drug delivery, pulmonary delivery, oral delivery, nasal delivery, transdermal delivery, circulation time, biodistribution, excretion, blood-brain barrier
Polymeric nanoparticle delivery systems have the potential to signicantly impact the treatment of cancer. Nanoparticle drug delivery systems offer the ability to design a delivery vehicle that maximizes the therapeutic index of a drug encapsulated into nanoparticles (NPs), target it to cancerous tissue, and release it in a controlled manner for optimal dosing. This chapter describes the barriers associated with various delivery routes, specically tissue, cellular, and molecular. Nanoparticle delivery approaches across tissue barriers
CONTENTS
Abstract ...................................................................................................................85 Introduction ...........................................................................................................86 Clinical Impact of NPDDS ................................................................................... 87 Crossing Epithelial Barriers .................................................................................88
