ABSTRACT
This chapter focuses on the Interagency Regulatory Alternatives Group (IRAG) presentations in November of 1995 at the 16th Annual Meeting of the American College of Toxicology in Vienna, Virginia. The IRAG is composed of representatives of the Consumer Products Safety Commission, the Environmental Protection Agency, and the Food and Drug Administration. The organotypic models workgroup had as its mission: evaluation of data submitted on the isolated eyes and components of the eye that have been used to predict eye irritation potential. The chorioallantoic membrane-based (CAM-based) assays workgroup evaluated two general types of CAM-based assays; the hen’s egg test-CAM and chorioallantoic membrane vascular assay (CAMVA). Early on the IRAG had set as one of its objectives completion of an evaluation of methods pertaining to the Draize test and, as a consequence, dermal irritation became the second initiative undertaken. Development of in vitro assays for dermal irritation was also perceived to have progressed further compared to the ocular area.
