ABSTRACT
The causative external noxious stimuli (i.e., pesticides, solvents, formaldehyde, phenols, ethanols, factory and car exhausts, mycotoxins, heavy metals, natural gas, particulates) continue to enter and assault the body. At this stage, as the hypersensitivity occurs and progresses, the local area of the specic organ or the end organ per se becomes hyperactive and hypersensitive. Then even nonnoxious stimuli (perfumes, newsprint, detergents, etc.) appear to become the triggers for homeostatic dysfunction. As shown in Reversibility of Chronic Disease and Hypersensitivity: Regulating Mechanisms of Chemical Sensitivity, the total body pollutant load is also as important as are the specic triggering agents in causing the increasing hypersensitivity as well as causing chronic degenerative disease. These external triggers eventually cause dyshomeostasis and end-organ failure as overuse of the repair nutrients depletes body’s healing capacity. Then dyshomeostasis usually occurs through the internal excitotoxin mechanism using glutamate (Glu) and aspartate and various other internal excitotoxins of which there are over seventy.3,4
Much evidence shows the relation of environmental pollutants and neuromusculoskeletal abnormalities. Our patients and communities are exposed to pesticides through air, food, and water or through dermal absorption. Thousands of pesticide products exist for many uses. In addition to insect, rodent, and landscape management, pesticides are also used in antimicrobial hand soaps, cosmetics, and cleaning products. Yet the impact of cumulative pesticide exposure and the synergistic effects of exposure to multiple pesticides and other chemicals are rarely considered. Typically, only the risks of acute exposure to an individual pesticide are assessed. Initial research indicates that neuromusculoskeletal, endocrine, immune, vascular, or developmental and degenerative effects increase when combined exposures are studied. The full health impact of multiple exposures to any one pesticide, or to multiple pesticides over an extended time, remains unknown.5 However, some studies and logic tell the clinician that multiple exposures could be debilitating and eventually lethal. Examples of the chronic effects of these exposures are shown in the following studies.
