ABSTRACT

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design.

chapter 1|4 pages

Introduction

chapter 2|22 pages

Camptothecin and Its Analogs

chapter 4|30 pages

Homoharringtonine and Related Compounds

chapter 5|28 pages

Podophyllotoxins and Analogs

chapter 6|54 pages

Taxol and its Analogs

chapter 7|22 pages

The Vinca Alkaloids

chapter 8|20 pages

The Bryostatins

chapter 15|20 pages

The Actinomycins

chapter 16|24 pages

Anthracyclines

chapter 17|22 pages

Ansamitocins (Maytansinoids)

chapter 18|22 pages

Benzoquinone Ansamycins

chapter 19|28 pages

Bleomycin Group Antitumor Agents

chapter 22|48 pages

Enediynes

chapter 23|24 pages

The Mitomycins